PDB_ID STRUCTURE TITLE DEPOSITION DATE RELEASE DATE AUTHORS TITLE JOURNAL YEAR VOLUME FIRST PAGE LAST PAGE 1KUG Crystal Structure of a Taiwan Habu Venom Metalloproteinase complexed with its endogenous inhibitor pENW 2002-01-22 2002-07-10 Huang, K.F.,Chiou, S.H.,Ko, T.P.,Wang, A.H. Determinants of the inhibition of a Taiwan habu venom metalloproteinase by its endogenous inhibitors revealed by X-ray crystallography and synthetic inhibitor analogues. Eur.J.Biochem. 2002 269 3047 3056 1KUK Crystal Structure of a Taiwan Habu Venom Metalloproteinase complexed with pEKW. 2002-01-22 2002-07-10 Huang, K.F.,Chiou, S.H.,Ko, T.P.,Wang, A.H. Determinants of the inhibition of a Taiwan habu venom metalloproteinase by its endogenous inhibitors revealed by X-ray crystallography and synthetic inhibitor analogues. Eur.J.Biochem. 2002 269 3047 3056 1MZ8 CRYSTAL STRUCTURES OF THE NUCLEASE DOMAIN OF COLE7/IM7 IN COMPLEX WITH A PHOSPHATE ION AND A ZINC ION 2002-10-07 2002-12-23 Sui, M.J.,Tsai, L.C.,Hsia, K.C.,Doudeva, L.G.,Ku, W.Y.,Han, G.W.,Yuan, H.S. Metal ions and phosphate binding in the H-N-H motif: crystal structures of the nuclease domain of ColE7/Im7 in complex with a phosphate ion and different divalent metal ions PROTEIN SCI. 2002 11 2947 2957 1NB2 Crystal Structure of Nucleoside Diphosphate Kinase from Bacillus Halodenitrificans 2002-12-02 2003-05-06 Chen, C.-J.,Liu, M.-Y.,Chang, T.,Chang, W.-C.,Wang, B.-C.,Le Gall, J. Crystal structure of a nucleoside diphosphate kinase from Bacillus halodenitrificans: coexpression of its activity with a Mn-superoxide dismutase. J.Struct.Biol. 2003 142 247 255 1J00 E. coli Thioesterase I/Protease I/Lysophospholipase L1 in complexed with diethyl phosphono moiety 2002-10-18 2003-07-08 Lo, Y.-C.,Lin, S.-C.,Shaw, J.-F.,Liaw, Y.-C. Crystal Structure of Escherichia coli Thioesterase I/Protease I/Lysophospholipase L1: Consensus Sequence Blocks Constitute the Catalytic Center of SGNH-hydrolases through a Conserved Hydrogen Bond Network J.Mol.Biol. 2003 330 539 551 1JRL Crystal structure of E. coli Lysophospholiase L1/Acyl-CoA Thioesterase I/Protease I L109P mutant 2001-08-14 2003-07-08 Lo, Y.-C.,Lin, S.-C.,Shaw, J.-F.,Liaw, Y.-C. Crystal Structure of Escherichia coli Thioesterase I/Protease I/Lysophospholipase L1: Consensus Sequence Blocks Constitute the Catalytic Center of SGNH-hydrolases through a Conserved Hydrogen Bond Network J.Mol.Biol. 2003 330 539 551 1UDV Crystal structure of the hyperthermophilic archaeal dna-binding protein Sso10b2 at 1.85 A 2003-05-07 2003-08-05 Chou, C.C.,Lin, T.W.,Chen, C.Y.,Wang, A.H.J. Crystal structure of the hyperthermophilic archaeal DNA-binding protein Sso10b2 at a resolution of 1.85 Angstroms J.BACTERIOL. 2003 185 4066 4073 1UEH E. coli undecaprenyl pyrophosphate synthase in complex with Triton X-100, magnesium and sulfate 2003-05-15 2003-08-12 Chang, S.-Y.,Ko, T.-P.,Liang, P.-H.,Wang, A.H.-J. Catalytic mechanism revealed by the crystal structure of undecaprenyl pyrophosphate synthase in complex with sulfate, magnesium, and triton J.Biol.Chem. 2003 278 29298 29307 1V4L Crystal structure of a platelet agglutination factor isolated from the venom of Taiwan habu (Trimeresurus mucrosquamatus) 2003-11-14 2003-12-02 Huang, K.F.,Ko, T.P.,Hung, C.C.,Chu, J.,Wang, A.H.,Chiou, S.H. Crystal structure of a platelet-agglutinating factor isolated from the venom of Taiwan habu (Trimeresurus mucrosquamatus). Biochem.J. 2004 378 399 407 1RJQ The crystal structure of the D-aminoacylase mutant D366A 2003-11-20 2004-04-20 Lai, W.L.,Chou, L.Y.,Ting, C.Y.,Kirby, R.,Tsai, Y.C.,Wang, A.H.,Liaw, S.H. The functional role of the binuclear metal center in D-aminoacylase: one-metal activation and second-metal attenuation. J.Biol.Chem. 2004 279 13962 13967 1RJR The crystal structure of the D-aminoacylase D366A mutant in complex with 100mM ZnCl2 2003-11-20 2004-04-20 Lai, W.L.,Chou, L.Y.,Ting, C.Y.,Kirby, R.,Tsai, Y.C.,Wang, A.H.,Liaw, S.H. The functional role of the binuclear metal center in D-aminoacylase: one-metal activation and second-metal attenuation. J.Biol.Chem. 2004 279 13962 13967 1RK5 The D-aminoacylase mutant D366A in complex with 100mM CuCl2 2003-11-20 2004-04-20 Lai, W.L.,Chou, L.Y.,Ting, C.Y.,Kirby, R.,Tsai, Y.C.,Wang, A.H.,Liaw, S.H. The functional role of the binuclear metal center in D-aminoacylase: one-metal activation and second-metal attenuation. J.Biol.Chem. 2004 279 13962 13967 1VG7 Crystal Structure Of Octaprenyl Pyrophosphate Synthase From Hyperthermophilic Thermotoga Maritima F132A/L128A/I123A/D62A mutant 2004-04-23 2004-05-18 Guo, R.T.,Kuo, C.J.,Ko, T.P.,Chou, C.C.,Liang, P.H.,Wang, A.H.-J. A molecular ruler for chain elongation catalyzed by octaprenyl pyrophosphate synthase and its structure-based engineering to produce unprecedented long chain trans-prenyl products Biochemistry 2004 43 7678 7686 1V1Q CRYSTAL STRUCTURE OF PRIB- A PRIMOSOMAL DNA REPLICATION PROTEIN OF ESCHERICHIA COLI 2004-04-22 2004-10-25 Liu, J.H.,Chang, T.W.,Huang, C.Y.,Chen, S.U.,Wu, H.N.,Chang, M.C.,Hsiao, C.D. Crystal structure of PriB, a primosomal DNA replication protein of Escherichia coli. J.Biol.Chem. 2004 279 50465 50471 1U26 Crystal structure of Selenomonas ruminantium phytase complexed with persulfated phytate 2004-07-16 2004-11-09 Chu, H.M.,Guo, R.T.,Lin, T.W.,Chou, C.C.,Shr, H.L.,Lai, H.L.,Tang, T.Y.,Cheng, K.J.,Selinger, B.L.,Wang, A.H.-J. Structures of Selenomonas ruminantium Phytase in Complex with Persulfated Phytate; DSP Phytase Fold and Mechanism for Sequential Substrate Hydrolysis STRUCTURE 2004 12 2015 2024 1WM3 Crystal structure of human SUMO-2 protein 2004-07-02 2004-11-30 Huang, W.-C.,Ko, T.-P.,Li, S.S.-L.,Wang, A.H.-J. Crystal structures of the human SUMO-2 protein at 1.6 A and 1.2 A resolution: implication on the functional differences of SUMO proteins Eur.J.Biochem. 2004 271 4114 4122 1V2G The L109P mutant of E. coli Thioesterase I/Protease I/Lysophospholipase L1 (TAP) in complexed with octanoic acid 2003-10-15 2004-12-14 Lo, Y.-C.,Lin, S.-C.,Shaw, J.-F.,Liaw, Y.-C. Substrate specificities of Escherichia coli thioesterase I/protease I/lysophospholipase L1 are governed by its switch loop movement Biochemistry 2005 44 1971 1979 1XT3 Structure Basis of Venom Citrate-Dependent Heparin Sulfate-Mediated Cell Surface Retention of Cobra Cardiotoxin A3 2004-10-21 2004-12-14 Lee, S.-C.,Guan, H.-H.,Wang, C.-H.,Huang, W.-N.,Tjong, S.-C.,Chen, C.-J.,Wu, W.-G. Structural basis of citrate-dependent and heparan sulfate-mediated cell surface retention of cobra cardiotoxin A3 J.Biol.Chem. 2005 280 9567 9577 1XYI Hyperthermophile chromosomal protein Sac7d double mutant Val26Ala/Met29Ala in complex with DNA GCGATCGC 2004-11-10 2005-02-08 Chen, C.-Y.,Ko, T.-P.,Lin, T.-W.,Chou, C.-C.,Chen, C.-J.,Wang, A.H.-J. Probing the DNA kink structure induced by the hyperthermophilic chromosomal protein Sac7d Nucleic Acids Res. 2005 33 430 438 1PKU Crystal Structure of Nucleoside Diphosphate Kinase from Rice 2003-06-06 2005-02-22 Huang, J.Y.,Chang, T.,Chang, C.Y.,Chen, C.J. Crystal structure of nucleoside diphosphate kinase required for coleoptile elongation in rice (Oryza sativa L.). J.Struct.Biol. 2005 150 309 318 1WTO Hyperthermophile chromosomal protein SAC7D double mutant V26F/M29F in complex with DNA GCGATCGC 2004-11-29 2005-02-22 Chen, C.-Y.,Ko, T.-P.,Lin, T.-W.,Chou, C.-C.,Chen, C.-J.,Wang, A.H.-J. Probing the DNA kink structure induced by the hyperthermophilic chromosomal protein Sac7d NUCLEIC ACIDS RES. 2005 33 430 438 1WTV Hyperthermophile chromosomal protein SAC7D single mutant M29A in complex with DNA GTAATTAC 2004-11-29 2005-02-22 Chen, C.-Y.,Ko, T.-P.,Lin, T.-W.,Chou, C.-C.,Chen, C.-J.,Wang, A.H.-J. Probing the DNA kink structure induced by the hyperthermophilic chromosomal protein Sac7d NUCLEIC ACIDS RES. 2005 33 430 438 1VF8 The Crystal Structure of Ym1 at 1.31 A Resolution 2004-04-09 2005-03-15 Tsai, M.L.,Liaw, S.H.,Chang, N.C. The crystal structure of Ym1 at 1.31 A resolution J.Struct.Biol. 2004 148 290 296 1X06 Crystal structure of undecaprenyl pyrophosphate synthase in complex with Mg, IPP and Fspp 2005-03-15 2005-03-22 Guo, R.T.,Ko, T.P.,Chen, A.P.,Kuo, C.J.,Wang, A.H.,Liang, P.H. Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J.Biol.Chem. 2005 280 20762 20774 1X08 Crystal structure of D26A mutant UPPs in complex with Mg, IPP and FsPP 2005-03-15 2005-03-22 Guo, R.T.,Ko, T.P.,Chen, A.P.,Kuo, C.J.,Wang, A.H.,Liang, P.H. Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J.Biol.Chem. 2005 280 20762 20774 1X09 Crystal structure of the D26A mutant UPPs in complex with magnesium and isopentenyl pyrophosphate 2005-03-15 2005-03-22 Guo, R.T.,Ko, T.P.,Chen, A.P.,Kuo, C.J.,Wang, A.H.,Liang, P.H. Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J.Biol.Chem. 2005 280 20762 20774 2BHI CRYSTAL STRUCTURE OF TAIWAN COBRA CARDIOTOXIN A3 COMPLEXED WITH SULFOGALACTOCERAMIDE 2005-01-12 2005-11-28 Wang, C.-H.,Liu, J.-H.,Lee, S.-C.,Hsiao, C.-D.,Wu, W.-G. Glycosphingolipid-Facilitated Membrane Insertion and Internalization of Cobra Cardiotoxin: The Sulfatide/Cardiotoxin Complex Structure in a Membrane-Like Environment Suggests a Lipid-Dependent Cell-Penetrating Mechanism for Membrane Binding Polypeptides. To be Published 0 0 0 0 1XTA Crystal Structure of Natrin, a snake venom CRISP from Taiwan cobra (Naja atra) 2004-10-21 2005-12-13 Wang, Y.-L.,Goh, K.-X.,Lee, S.-C.,Huang, W.-N.,Wu, W.-G.,Chen, C.-J. Structures of snake venom CRISP reveal an action mechanism involving serine protease and ion channel blocking domains To be Published 0 0 0 0 2DH4 Geranylgeranyl pyrophosphate synthase 2006-03-22 2006-04-04 Chang, T.-H.,Guo, R.-T.,Ko, T.-P.,Wang, A.H.,Liang, P.-H. Crystal Structure of Type-III Geranylgeranyl Pyrophosphate Synthase from Saccharomyces cerevisiae and the Mechanism of Product Chain Length Determination. J.Biol.Chem. 2006 281 14991 15000 2C6Y CRYSTAL STRUCTURE OF INTERLEUKIN ENHANCER-BINDING FACTOR 1 BOUND TO DNA 2005-11-15 2006-04-18 Tsai, K.-L.,Huang, C.-Y.,Chang, C.-H.,Sun, Y.-J.,Chuang, W.-J.,Hsiao, C.-D. Crystal Structure of Interleukin Enhancer-Binding Factor 1 Bound to DNA To be Published 0 0 0 0 2G0G Structure-based drug design of a novel family of PPAR partial agonists: virtual screening, x-ray crystallography and in vitro/in vivo biological activities 2006-02-13 2006-05-16 Lu, I.L.,Huang, C.F.,Peng, Y.H.,Lin, Y.T.,Hsieh, H.P.,Chen, C.T.,Lien, T.W.,Lee, H.J.,Mahindroo, N.,Prakash, E.,Yueh, A.,Chen, H.Y.,Goparaju, C.M.,Chen, X.,Liao, C.C.,Chao, Y.S.,Hsu, J.T.,Wu, S.Y. Structure-Based Drug Design of a Novel Family of PPARgamma Partial Agonists: Virtual Screening, X-ray Crystallography, and in Vitro/in Vivo Biological Activities J.Med.Chem. 2006 49 2703 2712 2DF7 Crystal structure of infectious bursal disease virus VP2 subviral particle 2006-02-27 2006-06-27 Lee, C.C.,Ko, T.P.,Chou, C.C.,Yoshimura, M.,Doong, S.R.,Wang, M.Y.,Wang, A.H. Crystal structure of infectious bursal disease virus VP2 subviral particle at 2.6A resolution: Implications in virion assembly and immunogenicity. J.Struct.Biol. 2006 155 74 86 2ATH Crystal structure of the ligand binding domain of human PPAR-gamma im complex with an agonist 2005-08-25 2006-08-25 Mahindroo, N.,Huang, C.-F.,Peng, Y.-H.,Wang, C.-C.,Liao, C.-C.,Lien, T.-W.,Chittimalla, S.K.,Huang, W.-J.,Chai, C.-H.,Prakash, E.,Chen, C.-P.,Hsu, T.-A.,Peng, C.-H.,Lu, I.-L.,Lee, L.-H.,Chang, Y.-W.,Chen, W.-C.,Chou, Y.-C.,Chen, C.-T.,Goparaju, C.M.V.,Chen, Y.-S.,Lan, S.-J.,Yu, M.-C.,Chen, X.,Chao, Y.-S.,Wu, S.-Y.,Hsieh, H.-P. Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities J.Med.Chem. 2005 48 8194 8208 2GZ9 Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of SARS-CoV Main Protease 2006-05-11 2006-08-29 Lu, I.L.,Mahindroo, N.,Liang, P.H.,Peng, Y.H.,Kuo, C.J.,Tsai, K.C.,Hsieh, H.P.,Chao, Y.S.,Wu, S.Y. Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Main Protease J.Med.Chem. 2006 49 5154 5161 2CCZ CRYSTAL STRUCTURE OF E. COLI PRIMOSOMOL PROTEIN PRIB BOUND TO SSDNA 2006-01-19 2006-09-18 Huang, C.Y.,Hsu, C.H.,Sun, Y.J.,Wu, H.N.,Hsiao, C.D. Complexed crystal structure of replication restart primosome protein PriB reveals a novel single-stranded DNA-binding mode. Nucleic Acids Res. 2006 34 3878 3886 2BQY INORGANIC PYROPHOSPHATASE FROM THE PATHOGENIC BACTERIUM HELICOBACTER PYLORI-KINETIC AND STRUCTURAL PROPERTIES 2005-04-07 2006-10-18 Chao, T.-C.,Huang, H.,Tsai, J.Y.,Huang, C.Y.,Sun, Y.-J. Kinetic and Structural Properties of Inorganic Pyrophosphatase from the Pathogenic Bacterium Helicobacter Pylori. To be Published 0 0 0 0 2DFL Crystal structure of left-handed RadA filament 2006-03-02 2007-01-23 Chen, L.T.,Ko, T.P.,Chang, Y.C.,Lin, K.A.,Chang, C.S.,Wang, A.H.J.,Wang, T.F. Crystal structure of the left-handed archaeal RadA helical filament: identification of a functional motif for controlling quaternary structures and enzymatic functions of RecA family proteins Nucleic Acids Res. 2007 35 1787 1801 2J3E DIMERIZATION IS IMPORTANT FOR THE GTPASE ACTIVITY OF CHLOROPLAST TRANSLOCON COMPONENTS ATTOC33 AND PSTOC159 2006-08-21 2007-03-27 Yeh, Y.-H.,Kesavulu, M.M.,Wu, S.-Z.,Li, H.-M.,Sun, Y.-J.,Konozy, E.H.,Hsiao, C.-D. Dimerization is Important for the Gtpase Activity of Chloroplast Translocon Components Attoc33 and Pstoc159 To be Published 0 0 0 0 2CMG CRYSTAL STRUCTURE OF SPERMIDINE SYNTHASE FROM HELICOBACTER PYLORI 2006-05-08 2007-05-08 Lu, P.-K.,Tsai, J.-Y.,Chien, H.Y.,Huang, H.,Chu, C.-H.,Sun, Y.-J. Crystal Structure of Helicobacter Pylori Spermidine Synthase: A Rossmann-Like Fold with a Distinct Active Site Proteins: Struct., Funct., Bio 2007 67 743 0