PDB_ID STRUCTURE TITLE DEPOSITION DATE RELEASE DATE AUTHORS TITLE JOURNAL YEAR VOLUME FIRST PAGE LAST PAGE 2IN4 Crystal Structure of Myoglobin with Charge Neutralized Heme, ZnDMb-dme 2006-10-05 2006-10-31 Wheeler, K.E.,Nocek, J.M.,Cull, D.A.,Yatsunyk, L.A.,Rosenzweig, A.C.,Hoffman, B.M. Dynamic Docking in Metal-Globins and Cytochrome b5: Insights into Reactive Complex Formation TO BE PUBLISHED 0 0 0 0 2NV6 Mycobacterium tuberculosis InhA (S94A) bound with INH-NAD adduct 2006-11-10 2006-11-21 Vilcheze, C.,Wang, F.,Arai, M.,Hazbon, M.H.,Colangeli, R.,Kremer, L.,Weisbrod, T.R.,Alland, D.,Sacchettini, J.C.,Jacobs Jr., W.R. Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid. Nat.Med 2006 12 1027 1029 2I46 Crystal structure of human TPP1 2006-08-21 2006-11-28 Wang, F.,Podell, E.R.,Zaug, A.J.,Yang, Y.,Baciu, P.,Cech, T.R.,Lei, M. The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature 2007 445 506 510 2NSN Crystal structure of Caspace Activation and Recruitment Domain (CARD) of NOD1 2006-11-05 2006-12-19 Coussens, N.P.,Mowers, J.C.,McDonald, C.,Nunez, G.,Ramaswamy, S. Crystal structure of the Nod1 caspase activation and recruitment domain. Biochem.Biophys.Res.Commun. 2007 353 1 5 2O40 Crystal Structure of a Chemically Synthesized 203 Amino Acid 'Covalent Dimer' HIV-1 Protease Molecule 2006-12-02 2006-12-19 Torbeev, V.Y.,Kent, S.B. Convergent chemical synthesis and crystal structure of a 203 amino acid "covalent dimer" HIV-1 protease enzyme molecule. Angew.Chem.Int.Ed.Engl. 2007 46 1667 1670 2NSX Structure of acid-beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease 2006-11-06 2006-12-26 Lieberman, R.L.,Wustman, B.A.,Huertas, P.,Powe, A.C.,Pine, C.W.,Khanna, R.,Schlossmacher, M.G.,Ringe, D.,Petsko, G.A. Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease. Nat.Chem.Biol. 2007 3 101 107 2NT0 Acid-beta-glucosidase low pH, glycerol bound 2006-11-06 2006-12-26 Lieberman, R.L.,Wustman, B.A.,Huertas, P.,Powe, A.C.,Pine, C.W.,Khanna, R.,Schlossmacher, M.G.,Ringe, D.,Petsko, G.A. Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease. Nat.Chem.Biol. 2007 3 101 107 2NT1 Structure of acid-beta-glucosidase at neutral pH 2006-11-06 2006-12-26 Lieberman, R.L.,Wustman, B.A.,Huertas, P.,Powe, A.C.,Pine, C.W.,Khanna, R.,Schlossmacher, M.G.,Ringe, D.,Petsko, G.A. Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease. Nat.Chem.Biol. 2007 3 101 107 2H9I Mycobacterium tuberculosis InhA bound with ETH-NAD adduct 2006-06-09 2007-01-30 Wang, F.,Langley, R.,Gulten, G.,Dover, L.G.,Besra, G.S.,Jacobs, W.R.,Sacchettini, J.C. Mechanism of thioamide drug action against tuberculosis and leprosy. J.Exp.Med. 2007 204 73 78 2NTV Mycobacterium leprae InhA bound with PTH-NAD adduct 2006-11-08 2007-01-30 Wang, F.,Langley, R.,Gulten, G.,Dover, L.G.,Besra, G.S.,Jacobs, W.R.,Sacchettini, J.C. Mechanism of thioamide drug action against tuberculosis and leprosy. J.Exp.Med. 2007 204 73 78 2OKQ Crystal structure of unknown conserved ybaA protein from Shigella flexneri 2007-01-17 2007-02-06 Minasov, G.,Vorontsov, I.I.,Shuvalova, L.,Brunzelle, J.S.,Kiryukhina, O.,Collart, F.R.,Joachimiak, A.,Anderson, W.F. Crystal structure of unknown conserved ybaA protein from Shigella flexneri TO BE PUBLISHED 0 0 0 0 2E25 The Crystal Structure of the T109S mutant of E. coli Dihydroorotase complexed with an inhibitor 5-fluoroorotate 2006-11-08 2007-03-13 Lee, M.,Maher, M.J.,Guss, J.M. Structure of the T109S mutant of Escherichia coli dihydroorotase complexed with the inhibitor 5-fluoroorotate: catalytic activity is reflected by the crystal form Acta Crystallogr.,Sect.F 2007 63 154 161 2NVO Crystal structure of Deinococcus radiodurans RO (RSR) protein 2006-11-13 2007-03-27 Ramesh, A.,Savva, C.G.,Holzenburg, A.,Sacchettini, J.C. Crystal structure of Rsr, an ortholog of the antigenic Ro protein, links conformational flexibility to RNA binding activity. J.Biol.Chem. 2007 282 14960 14967 2O0H T4 gp17 ATPase domain mutant complexed with ATP 2006-11-27 2007-04-03 Sun, S.,Kondabagil, K.,Gentz, P.M.,Rossmann, M.G.,Rao, V.B. The Structure of the ATPase that Powers DNA Packaging into Bacteriophage T4 Procapsids MOL.CELL 2007 25 943 949 2O0J T4 gp17 ATPase domain mutant complexed with ADP 2006-11-27 2007-04-03 Sun, S.,Kondabagil, K.,Gentz, P.M.,Rossmann, M.G.,Rao, V.B. The Structure of the ATPase that Powers DNA Packaging into Bacteriophage T4 Procapsids MOL.CELL 2007 25 943 949 2O0K T4 gp17 ATPase domain mutant 2006-11-27 2007-04-03 Sun, S.,Kondabagil, K.,Gentz, P.M.,Rossmann, M.G.,Rao, V.B. The Structure of the ATPase that Powers DNA Packaging into Bacteriophage T4 Procapsids MOL.CELL 2007 25 943 949 2PA3 crystal structure of serine bound G336V mutant of E.coli phosphoglycerate dehydrogenase 2007-03-27 2007-04-24 Dey, S.,Hu, Z.,Xu, X.L.,Sacchettini, J.C.,Grant, G.A. The Effect of Hinge Mutations on Effector Binding and Domain Rotation in Escherichia coli D-3-Phosphoglycerate Dehydrogenase. J.Biol.Chem. 2007 282 18418 18426 2OZK Structure of an N-Terminal Truncated Form of Nendou (NSP15) From SARS-CORONAVIRUS 2007-02-26 2007-05-29 Joseph, J.S.,Saikatendu, K.S.,Subramanian, V.,Neuman, B.W.,Buchmeier, M.J.,Stevens, R.C.,Kuhn, P. Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch. J.Virol. 2007 81 6700 6708 2PKF Crystal structure of M tuberculosis Adenosine Kinase (apo) 2007-04-17 2007-06-19 Reddy, M.C.M.,Palaninathan, S.K.,Shetty, N.D.,Owen, J.L.,Watson, M.D.,Sacchettini, J.C. High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme J.Biol.Chem. 2007 282 27334 27342 2QKQ Structure of the SAM Domain of Human Ephrin Type-B Receptor 4 2007-07-11 2007-07-24 Walker, J.R.,Cuerrier, D.,Butler-Cole, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S. SAM Domain of Human Ephrin Type-B Receptor 4 (EPHB4) TO BE PUBLISHED 0 0 0 0 2QPP Crystal structure of human heme oxygenase-2 C127A (HO-2) with bound heme 2007-07-24 2007-08-07 Bianchetti, C.M.,Yi, L.,Ragsdale, S.W.,Phillips Jr., G.N. Comparison of Apo- and Heme-bound Crystal Structures of a Truncated Human Heme Oxygenase-2. J.Biol.Chem. 2007 282 37624 37631 2QNK Crystal structure of human 3-hydroxyanthranilate 3,4-dioxygenase 2007-07-18 2007-08-14 Bitto, E.,Bingman, C.A.,Wesenberg, G.E.,Phillips Jr., G.N. Crystal Structure of Human 3-hydroxyanthranilate 3,4-dioxygenase. to be published 0 0 0 0 2QT8 Coproporphyrinogen III oxidase from Leishmania major 2007-08-01 2007-09-04 Merritt, E.A.,Le Trong, I. Coproporphyrinogen III oxidase from Leishmania major. To be Published 0 0 0 0 2R2O Crystal structure of the effector domain of human Plexin B1 2007-08-27 2007-09-04 Tong, Y.,Chugha, P.,Hota, P.K.,Alviani, R.S.,Li, M.,Tempel, W.,Shen, L.,Park, H.W.,Buck, M. Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain. J.Biol.Chem. 2007 282 37215 37224 2IGB Crystal Structure of PyrR, The Regulator Of The Pyrimidine Biosynthetic Operon In Bacillus caldolyticus, UMP-bound form 2006-09-22 2007-09-25 Chander, P.,Switzer, R.L.,Smith, J.L. PyrR, the regulator of the pyrimidine biosynthetic operon in Bacillus caldolyticus To be Published 0 0 0 0 2R2P Kinase domain of human ephrin type-A receptor 5 (EphA5) 2007-08-27 2007-09-25 Walker, J.R.,Cuerrier, D.,Butler-Cole, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S. Kinase Domain of Human Ephrin Type-A Receptor 5 (EphA5). To be Published 0 0 0 0 2RC3 Crystal structure of CBS domain, NE2398 2007-09-19 2007-10-02 Dong, A.,Xu, X.,Edwards, A.M.,Chang, C.,Chruszcz, M.,Cuff, M.,Cymborowski, M.,Di Leo, R.,Egorova, O.,Evdokimova, E.,Filippova, E.,Gu, J.,Guthrie, J.,Ignatchenko, A.,Joachimiak, A.,Klostermann, N.,Kim, Y.,Korniyenko, Y.,Minor, W.,Que, Q.,Savchenko, A.,Skarina, T.,Tan, K.,Yakunin, A.,Yee, A.,Yim, V.,Zhang, R.,Zheng, H.,Akutsu, M.,Arrowsmith, C.,Avvakumov, G.V.,Bochkarev, A.,Dahlgren, L.G.,Dhe-Paganon, S.,Dimov, S.,Dombrovski, L.,Finerty, P.,Flodin, S.,Flores, A.,Graslund, S.,Hammerstrom, M.,Herman, M.D.,Hong, B.S.,Hui, R.,Johansson, I.,Liu, Y.,Nilsson, M.,Nedyalkova, L.,Nordlund, P.,Nyman, T.,Min, J.,Ouyang, H.,Park, H.W.,Qi, C.,Rabeh, W.,Shen, L.,Shen, Y.,Sukumard, D.,Tempel, W.,Tong, Y.,Tresagues, L.,Vedadi, M.,Walker, J.R.,Weigelt, J.,Welin, M.,Wu, H.,Xiao, T.,Zeng, H.,Zhu, H. In situ proteolysis for protein crystallization and structure determination. Nat.Methods 2007 4 1019 1021 2Z26 Thr110Ala dihydroorotase from E. coli 2007-05-17 2007-10-09 Lee, M.,Maher, M.J.,Christopherson, R.I.,Guss, J.M. Kinetic and Structural Analysis of Mutant Escherichia coli Dihydroorotases: A Flexible Loop Stabilizes the Transition State Biochemistry 2007 46 10538 10550 2Z2B Deletion 107-116 mutant of dihydroorotase from E. coli 2007-05-17 2007-10-09 Lee, M.,Maher, M.J.,Christopherson, R.I.,Guss, J.M. Kinetic and Structural Analysis of Mutant Escherichia coli Dihydroorotases: A Flexible Loop Stabilizes the Transition State Biochemistry 2007 46 10538 10550 2REP Crystal structure of the motor domain of human kinesin family member C1 2007-09-26 2007-10-09 Zhu, H.,Tempel, W.,He, H.,Shen, Y.,Wang, J.,Brothers, G.,Landry, R.,Arrowsmith, C.H.,Edwards, A.M.,Sundstrom, M.,Weigelt, J.,Bochkarev, A.,Park, H. Crystal structure of the motor domain of human kinesin family member C1. To be Published 0 0 0 0 2Q2X Crystal Structure of the ECH2 decarboxylase domain of CurF from Lyngbya majuscula 2007-05-29 2007-10-09 Geders, T.W.,Gu, L.,Mowers, J.C.,Liu, H.,Gerwick, W.H.,Hakansson, K.,Sherman, D.H.,Smith, J.L. Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching. J.Biol.Chem. 2007 282 35954 35963 2Q34 Crystal Structure of the ECH2 decarboxylase domain of CurF from Lyngbya majuscula, rhombohedral crystal form 2007-05-29 2007-10-09 Geders, T.W.,Gu, L.,Mowers, J.C.,Liu, H.,Gerwick, W.H.,Hakansson, K.,Sherman, D.H.,Smith, J.L. Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching. J.Biol.Chem. 2007 282 35954 35963 2Q35 Crystal Structure of the Y82F variant of ECH2 decarboxylase domain of CurF from Lyngbya majuscula 2007-05-29 2007-10-09 Geders, T.W.,Gu, L.,Mowers, J.C.,Liu, H.,Gerwick, W.H.,Hakansson, K.,Sherman, D.H.,Smith, J.L. Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching. J.Biol.Chem. 2007 282 35954 35963 2RGZ Ensemble refinement of the protein crystal structure of human heme oxygenase-2 C127A (HO-2) with bound heme 2007-10-05 2007-10-23 Bianchetti, C.M.,Yi, L.,Ragsdale, S.W.,Phillips Jr., G.N. Comparison of Apo- and Heme-bound Crystal Structures of a Truncated Human Heme Oxygenase-2. J.Biol.Chem. 2007 282 37624 37631 2RH1 High resolution crystal structure of human B2-adrenergic G protein-coupled receptor 2007-10-05 2007-10-30 Cherezov, V.,Rosenbaum, D.M.,Hanson, M.A.,Rasmussen, S.G.,Thian, F.S.,Kobilka, T.S.,Choi, H.J.,Kuhn, P.,Weis, W.I.,Kobilka, B.K.,Stevens, R.C. High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science 2007 318 1258 1265 2RH1 High resolution crystal structure of human B2-adrenergic G protein-coupled receptor 2007-10-05 2007-10-30 Cherezov, V.,Rosenbaum, D.M.,Hanson, M.A.,Rasmussen, S.G.,Thian, F.S.,Kobilka, T.S.,Choi, H.J.,Kuhn, P.,Weis, W.I.,Kobilka, B.K.,Stevens, R.C. High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science 2007 318 1258 1265 2R4S Crystal structure of the human beta2 adrenoceptor 2007-08-31 2007-11-06 Rasmussen, S.G.,Choi, H.J.,Rosenbaum, D.M.,Kobilka, T.S.,Thian, F.S.,Edwards, P.C.,Burghammer, M.,Ratnala, V.R.,Sanishvili, R.,Fischetti, R.F.,Schertler, G.F.,Weis, W.I.,Kobilka, B.K. Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature 2007 450 383 387 2O4H Human brain aspartoacylase complex with intermediate analog (N-phosphonomethyl-L-aspartate) 2006-12-04 2007-11-06 Le Coq, J.,Pavlovsky, A.,Malik, R.,Sanishvili, R.,Xu, C.,Viola, R.E. Examination of the Mechanism of Human Brain Aspartoacylase through the Binding of an Intermediate Analogue. Biochemistry 2008 47 3484 3492 2O53 Crystal structure of apo-Aspartoacylase from human brain 2006-12-05 2007-11-06 Le Coq, J.,Pavlovsky, A.,Malik, R.,Sanishvili, R.,Xu, C.,Viola, R.E. Examination of the Mechanism of Human Brain Aspartoacylase through the Binding of an Intermediate Analogue. Biochemistry 2008 47 3484 3492 2REF Crystal structure of the loading GNATL domain of CurA from Lyngbya majuscula soaked with malonyl-CoA 2007-09-26 2007-11-20 Gu, L.,Geders, T.W.,Wang, B.,Gerwick, W.H.,Hakansson, K.,Smith, J.L.,Sherman, D.H. GNAT-like strategy for polyketide chain initiation. Science 2007 318 970 974 2REE Crystal structure of the loading GNATL domain of CurA from Lyngbya majuscula 2007-09-26 2007-11-20 Gu, L.,Geders, T.W.,Wang, B.,Gerwick, W.H.,Hakansson, K.,Smith, J.L.,Sherman, D.H. GNAT-like strategy for polyketide chain initiation. Science 2007 318 970 974 2V3Z GLU383ALA ESCHERICHIA COLI AMINOPEPTIDASE P IN COMPLEX WITH SUBSTRATE 2007-06-25 2007-11-20 Graham, S.C.,Guss, J.M. Complexes of Mutants of Escherichia Coli Aminopeptidase P and the Tripeptide Substrate Valproleu. Arch.Biochem.Biophys. 2008 469 200 0 2V3X HIS243ALA ESCHERICHIA COLI AMINOPEPTIDASE P IN COMPLEX WITH SUBSTRATE 2007-06-25 2007-11-20 Graham, S.C.,Guss, J.M. Complexes of Mutants of Escherichia Coli Aminopeptidase P and the Tripeptide Substrate Valproleu. Arch.Biochem.Biophys. 2008 469 200 0 2OY1 The crystal structure of OspA mutant 2007-02-21 2007-12-11 Makabe, K.,Yan, S.,Tereshko, V.,Gawlak, G.,Koide, S. beta-Strand Flipping and Slipping Triggered by Turn Replacement Reveal the Opportunistic Nature of beta-Strand Pairing J.Am.Chem.Soc. 2007 129 14661 14669 3BI7 Crystal structure of the SRA domain of E3 ubiquitin-protein ligase UHRF1 2007-11-30 2007-12-18 Avvakumov, G.V.,Walker, J.R.,Xue, S.,Li, Y.,Duan, S.,Bronner, C.,Arrowsmith, C.H.,Dhe-Paganon, S. Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1. Nature 2008 455 822 826 3BKH Crystal structure of the bacteriophage phiKZ lytic transglycosylase, gp144 2007-12-06 2008-01-08 Fokine, A.,Miroshnikov, K.A.,Shneider, M.M.,Mesyanzhinov, V.V.,Rossmann, M.G. Structure of the bacteriophage phi KZ lytic transglycosylase gp144 J.Biol.Chem. 2008 283 7242 7250 2VI6 CRYSTAL STRUCTURE OF THE NANOG HOMEODOMAIN 2007-11-28 2008-01-15 Jauch, R.,Ng, C.K.L.,Saitakendu, K.S.,Stevens, R.C.,Kolatkar, P.R. Crystal Structure and DNA Binding of the Homeodomain of the Stem Cell Transcription Factor Nanog. J.Mol.Biol. 2008 376 758 0 3BJU Crystal Structure of tetrameric form of human lysyl-tRNA synthetase 2007-12-04 2008-02-05 Guo, M.,Ignatov, M.,Musier-Forsyth, K.,Schimmel, P.,Yang, X.L. Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation Proc.Natl.Acad.Sci.Usa 2008 105 2331 2336 3C5H Crystal structure of the Ras homolog domain of human GRLF1 (p190RhoGAP) 2008-01-31 2008-02-12 Shen, L.,Tong, Y.,Tempel, W.,MacKenzie, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Bochkarev, A.,Park, H. Crystal structure of the Ras homolog domain of human GRLF1 (p190RhoGAP). To be Published 0 0 0 0 3C5I Crystal structure of Plasmodium knowlesi choline kinase, PKH_134520 2008-01-31 2008-02-19 Wernimont, A.K.,Hills, T.,Lew, J.,Wasney, G.,Senisterra, G.,Kozieradzki, I.,Cossar, D.,Vedadi, M.,Schapira, M.,Bochkarev, A.,Arrowsmith, C.H.,Bountra, C.,Weigelt, J.,Edwards, A.M.,Hui, R.,Artz, J.D.,Xiao, T. Crystal structure of Plasmodium knowlesi choline kinase, PKH_134520. To be Published 0 0 0 0 3BU8 Crystal Structure of TRF2 TRFH domain and TIN2 peptide complex 2008-01-02 2008-02-19 Chen, Y.,Yang, Y.,van Overbeek, M.,Donigian, J.R.,Baciu, P.,de Lange, T.,Lei, M. A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science 2008 319 1092 1096 3BZH Crystal structure of human ubiquitin-conjugating enzyme E2 E1 2008-01-18 2008-02-26 Walker, J.R.,Avvakumov, G.V.,Xue, S.,Li, Y.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S. Human Ubiquitin-Conjugating Enzyme E2 E1. To be Published 0 0 0 0 3C1M Cyrstal Structure of threonine-sensitive aspartokinase from Methanococcus jannaschii with MgAMP-PNP and L-aspartate 2008-01-23 2008-03-25 Liu, X.,Pavlovsky, A.G.,Viola, R.E. The Structural Basis for Allosteric Inhibition of a Threonine-sensitive Aspartokinase. J.Biol.Chem. 2008 283 16216 16225 2R16 Crystal Structure of bovine neurexin 1 alpha LNS/LG domain 4 (with no splice insert) 2007-08-22 2008-03-25 Shen, K.C.,Kuczynska, D.A.,Wu, I.J.,Murray, B.H.,Sheckler, L.R.,Rudenko, G. Regulation of Neurexin 1beta Tertiary Structure and Ligand Binding through Alternative Splicing Structure 2008 16 422 431 3BT1 Structure of urokinase receptor, urokinase and vitronectin complex 2007-12-27 2008-03-25 Huai, Q.,Zhou, A.,Lin, L.,Mazar, A.P.,Parry, G.C.,Callahan, J.,Shaw, D.E.,Furie, B.,Furie, B.C.,Huang, M. Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes Nat.Struct.Mol.Biol. 2008 15 422 423 3CKL Crystal structure of human cytosolic sulfotransferase SULT1B1 in complex with PAP and resveratrol 2008-03-16 2008-04-01 Pan, P.W.,Tempel, W.,Dong, A.,Loppnau, P.,Kozieradzki, I.,Edwards, A.M.,Arrowsmith, C.H.,Weigelt, J.,Bountra, C.,Bochkarev, A.,Min, J. Crystal structure of human cytosolic sulfotransferase SULT1B1 in complex with PAP and resveratrol. To be Published 0 0 0 0 3CKK Crystal structure of human methyltransferase-like protein 1 2008-03-16 2008-04-01 Zeng, H.,Dong, A.,Dobrovetsky, E.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Min, J.,Plotnikov, A.N.,Wu, H. Crystal structure of human methyltransferase-like protein 1. To be Published 0 0 0 0 3BEG Crystal structure of SR protein kinase 1 complexed to its substrate ASF/SF2 2007-11-18 2008-04-01 Ngo, J.C.,Giang, K.,Chakrabarti, S.,Ma, C.-T.,Huynh, N.,Hagopian, J.,Dorrestein, P.C.,Fu, X.-D.,Adams, J.A.,Ghosh, G. A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1 Mol.Cell 2008 29 563 576 3BUL E. coli I690C/G743C MetH C-terminal fragment (649-1227) 2008-01-03 2008-04-01 Datta, S.,Koutmos, M.,Pattridge, K.A.,Ludwig, M.L.,Matthews, R.G. A disulfide-stabilized conformer of methionine synthase reveals an unexpected role for the histidine ligand of the cobalamin cofactor. Proc.Natl.Acad.Sci.Usa 2008 105 4115 4120 3CEG Crystal structure of the UBC domain of baculoviral IAP repeat-containing protein 6 2008-02-29 2008-04-01 Walker, J.R.,Avvakumov, G.V.,Xue, S.,Butler-Cole, C.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S. UBC Domain of the Ubiquitin-Protein Ligase Baculoviral IAP Repeat-Containing Protein 6. To be Published 0 0 0 0 2PFC Structure of Mycobacterium tuberculosis Rv0098 2007-04-04 2008-04-08 Wang, F.,Langley, R.,Gulten, G.,Wang, L.,Sacchettini, J.C. Identification of a type III thioesterase reveals the function of an operon crucial for Mtb virulence. Chem.Biol. 2007 14 543 551 3CLZ The set and ring associated (SRA) domain of UHRF1 bound to methylated DNA 2008-03-20 2008-04-29 Avvakumov, G.V.,Walker, J.R.,Xue, S.,Li, Y.,Duan, S.,Bronner, C.,Arrowsmith, C.H.,Dhe-Paganon, S. Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1. Nature 2008 455 822 825 2Q7U Crystal Structure of the F plasmid TraI Relaxase Domain with the Scissile Thymidine Base and Imidodiphosphate 2007-06-07 2008-05-20 Lujan, S.A.,Guogas, L.M.,Ragonese, H.,Matson, S.W.,Redinbo, M.R. Disrupting antibiotic resistance propagation by inhibiting the conjugative DNA relaxase. Proc.Natl.Acad.Sci.Usa 2007 104 12282 12287 2VPW POLYSULFIDE REDUCTASE WITH BOUND MENAQUINONE 2008-03-09 2008-06-10 Jormakka, M.,Yokoyama, K.,Yano, T.,Tamakoshi, M.,Akimoto, S.,Shimamura, T.,Curmi, P.,Iwata, S. Molecular Mechanism of Energy Conservation in Polysulfide Respiration To be Published 0 0 0 0 2VPY POLYSULFIDE REDUCTASE WITH BOUND QUINONE INHIBITOR, PENTACHLOROPHENOL (PCP) 2008-03-09 2008-06-10 Jormakka, M.,Yokoyama, K.,Yano, T.,Tamakoshi, M.,Akimoto, S.,Shimamura, T.,Curmi, P.,Iwata, S. Molecular Mechanism of Energy Conservation in Polysulfide Respiration To be Published 0 0 0 0 2VPX POLYSULFIDE REDUCTASE WITH BOUND QUINONE (UQ1) 2008-03-09 2008-06-10 Jormakka, M.,Yokoyama, K.,Yano, T.,Tamakoshi, M.,Akimoto, S.,Shimamura, T.,Curmi, P.,Iwata, S. Molecular Mechanism of Energy Conservation in Polysulfide Respiration To be Published 0 0 0 0 2VPZ POLYSULFIDE REDUCTASE NATIVE STRUCTURE 2008-03-09 2008-06-10 Jormakka, M.,Yokoyama, K.,Yano, T.,Tamakoshi, M.,Akimoto, S.,Shimamura, T.,Curmi, P.,Iwata, S. Molecular Mechanism of Energy Conservation in Polysulfide Respiration To be Published 0 0 0 0 3D4S Cholesterol bound form of human beta2 adrenergic receptor 2008-05-14 2008-06-17 Hanson, M.A.,Cherezov, V.,Griffith, M.T.,Roth, C.B.,Jaakola, V.P.,Chien, E.Y.,Velasquez, J.,Kuhn, P.,Stevens, R.C. A Specific Cholesterol Binding Site Is Established by the 2.8 A Structure of the Human beta(2)-Adrenergic Receptor. Structure 2008 16 897 905 3D38 Crystal structure of new trigonal form of photosynthetic reaction center from Blastochloris viridis. Crystals grown in microfluidics by detergent capture 2008-05-09 2008-07-08 Li, L.,Nachtergaele, S.H.M.,Seddon, A.M.,Tereshko, V.,Ponomarenko, N.,Ismagilov, R.F. Simple host-guest chemistry to modulate crystallization of membrane proteins by controlling detergent molecules. To be Published 0 0 0 0 3D89 Crystal Structure of a Soluble Rieske Ferredoxin from Mus musculus 2008-05-22 2008-07-15 Levin, E.J.,Elsen, N.L.,Seder, K.D.,McCoy, J.G.,Fox, B.G.,Phillips, G.N. X-ray structure of a soluble Rieske-type ferredoxin from Mus musculus. Acta Crystallogr.,Sect.D 2008 64 933 940 3CHX Crystal structure of Methylosinus trichosporium OB3b particulate methane monooxygenase (pMMO) 2008-03-10 2008-07-15 Hakemian, A.S.,Kondapalli, K.C.,Telser, J.,Hoffman, B.M.,Stemmler, T.L.,Rosenzweig, A.C. The metal centers of particulate methane monooxygenase from Methylosinus trichosporium OB3b. Biochemistry 2008 47 6793 6801 3BJI Structural Basis of Promiscuous Guanine Nucleotide Exchange by the T-Cell Essential Vav1 2007-12-04 2008-07-15 Chrencik, J.E.,Brooun, A.,Zhang, H.,Mathews, I.I.,Hura, G.L.,Foster, S.A.,Perry, J.J.,Streiff, M.,Ramage, P.,Widmer, H.,Bokoch, G.M.,Tainer, J.A.,Weckbecker, G.,Kuhn, P. Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1. J.Mol.Biol. 2008 380 828 843 3CSG Crystal Structure of Monobody YS1(MBP-74)/Maltose Binding Protein Fusion Complex 2008-04-09 2008-07-22 Gilbreth, R.N.,Esaki, K.,Koide, A.,Sidhu, S.S.,Koide, S. A Dominant Conformational Role for Amino Acid Diversity in Minimalist Protein-Protein Interfaces J.Mol.Biol. 2008 381 407 418 3DFA Crystal structure of kinase domain of calcium-dependent protein kinase cgd3_920 from Cryptosporidium parvum 2008-06-11 2008-07-29 Wernimont, A.K.,Lew, J.,Lin, L.,Hassanali, A.,Khuu, C.,Alam, Z.,Kozieradzki, I.,Cossar, D.,Bochkarev, A.,Arrowsmith, C.H.,Bountra, C.,Wilkstrom, M.,Edwards, A.M.,Hui, R.,Artz, J.D.,Xiao, T. Crystal structure of kinase domain of calcium-dependent protein kinase cgd3_920 from Cryptosporidium parvum. To be Published 0 0 0 0 2RGT Crystal Structure of Lhx3 LIM domains 1 and 2 with the binding domain of Isl1 2007-10-05 2008-08-12 Bhati, M.,Lee, C.,Nancarrow, A.L.,Lee, M.,Craig, V.J.,Bach, I.,Guss, J.M.,Mackay, J.P.,Matthews, J.M. Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes. Embo J. 2008 27 2018 2029 3CEQ The TPR domain of Human Kinesin Light Chain 2 (hKLC2) 2008-02-29 2008-08-12 Zhu, H.,Shen, Y.,MacKenzie, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Bochkarev, A.,Park, H. 0 0 0 0 3DCR X-ray structure of HIV-1 protease and hydrated form of ketomethylene isostere inhibitor 2008-06-04 2008-08-19 Torbeev, V.Y.,Mandal, K.,Terechko, V.A.,Kent, S.B.H. Crystal structure of chemically synthesized HIV-1 protease and a ketomethylene isostere inhibitor based on the p2/NC cleavage site Bioorg.Med.Chem.Lett. 2008 18 4554 4557 2ZNM Oxidoreductase NmDsbA3 from Neisseria meningitidis 2008-04-30 2008-08-19 Vivian, J.,Scoullar, J.,Robertson, A.L.,Bottomley, S.P.,Horne, J.,Chin, Y.,Velkov, T.,Wielens, J.,Thompson, P.E.,Peik, S.,Byres, E.,Beddoe, T.,Wilce, M.C.J.,Kahler, C.,Rossjohn, J.,Scanlon, M.J. Structural and biochemical characterisation of the oxidoreductase NmDsbA3 from Neisseria meningitidis J.Biol.Chem. 2008 0 0 0 3DOM Crystal Structure of the complex between Tfb5 and the C-terminal domain of Tfb2 2008-07-04 2008-08-19 Kainov, D.E.,Vitorino, M.,Cavarelli, J.,Poterszman, A.,Egly, J.M. Structural basis for group A trichothiodystrophy Nat.Struct.Mol.Biol. 2008 0 0 0 3EAP Crystal structure of the RhoGAP domain of ARHGAP11A 2008-08-26 2008-09-02 Shen, Y.,Shen, L.,Tong, Y.,Tempel, W.,MacKenzie, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Bochkarev, A.,Park, H. Crystal structure of the RhoGAP domain of ARHGAP11A To be Published 0 0 0 0 3DWR Leishmania major coproporphyrinogen III oxidase with bound ligand 2008-07-22 2008-09-09 Merritt, E.A.,Le Trong, I.,Larson, E.T.,Shibata, S.,Zhang, Z.,Anderson, L.,Ross, J.,Verlinde, C.L.M.J.,Buckner, F.S.,Van Voorhis, W.C.,Hol, G.J.W.,Fan, E. Leishmania major coproporphyrinogen III oxidase with bound ligand To be Published 0 0 0 0 3DB4 Crystal structure of the tandem tudor domains of the E3 ubiquitin-protein ligase UHRF1 2008-05-30 2008-09-16 Walker, J.R.,Avvakumov, G.V.,Xue, S.,Dong, A.,Li, Y.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S. Cryptic tandem tudor domains in UHRF1 interact with H3K9ME and are important for pericentric heterochromatin replication To be Published 0 0 0 0 3CO7 Crystal Structure of FoxO1 DBD Bound to DBE2 DNA 2008-03-27 2008-09-16 Brent, M.M.,Anand, R.,Marmorstein, R. Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification. Structure 2008 16 1407 1416 3EML The 2.6 A Crystal Structure of a Human A2A Adenosine Receptor bound to ZM241385. 2008-09-24 2008-10-14 Jaakola, V.P.,Griffith, M.T.,Hanson, M.A.,Cherezov, V.,Chien, E.Y.,Lane, J.R.,Ijzerman, A.P.,Stevens, R.C. The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist. Science 2008 0 0 0 3EQL Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic myxopyronin 2008-09-30 2008-10-28 Belogurov, G.,Vassylyeva, M.N.,Sevostyanova, A.,Appleman, J.R.,Xiang, A.X.,Lira, R.,Webber, S.E.,Klyuyev, S.,Nudler, E.,Artsimovitch, I.,Vassylyev, D.G. Transcription inactivation through local refolding of the RNA polymerase structure To be Published 0 0 0 0