The Advanced Photon Source (APS)

BioCARs

(Sector 14) The Consortium for Advanced Radiation Sources (CARS) is a multi-institutional (the Univ. of Chicago, Northern Illinois Univ., Southern Illinois Univ. at Carbondale, the University of Illinois at Chicago and the Australian Nuclear Science and Technology Organization (ANSTO)) multi-disiplinary consortium managed by the University of Chicago.

IMCA-CAT

(Sector 17) The Industrial Macromolecular Crystallography Association Collaborative Access Team, is dedicated to high-throughput macromolecular crystallography for pharmaceutical research in drug discovery. IMCA-CAT is funded by the pharmaceutical industry members of IMCA and is operated through the University of Chicago. Confidential and proprietary experiments are readily and easily accommodated. The beamlines are specially equipped with robotics for sample mounting, centering, screening, and data collection. Mail-in data collection with remote monitoring is offered.

SBC-CAT

(Sector 19) The Structural Biology Center, is funded by the DOE Office of Biological and Environmental Research. The majority of beamtime is allocated to Independent Investigators.

LS-CAT

(Sector 21) The Life Sciences Collaborative Access Team (LS-CAT) include four experimental stations using 2 insertion devices. The main beamline (21-ID-\ D) uses a shortend "Undulator" A and a Kohzu monochromator. In addition to the main beamline there are three experimental stations that share a single 3\ .0 CM undulator. The first two of these stations use diamond laue monochromators supplied by JJ X-Ray along with beryllium lenses to focus a beam monoch\ romatic x-rays onto the sample. This allows SAD experiments to be done at the selenium edge (12.668 KeV).

SER-CAT

(Secctor 22) The South East Regional Collaborative Access Team, consists of 24 member institutions across 11 states and the National Institutes of Health Intramural Program. SER-CAT is administered through the Department of Biochemistry and Molecular Biology at the University of Georgia. It stands out from other APS CATs in terms of its large diverse membership and its multiple sources of funding (mainly through state legislative funds, agencies, and the individual universities- at the university, department, or individual research group level).

DND-CAT

(Sector 5) The DuPont - Northwestern -Dow Collaborative Access Team(sector 5), was not originally designed for macromolecular crystallography experiments, although a considerable fraction of the research conducted there is now in this area. The Web page describing their program is located at the following address: http://tomato.dnd.aps.anl.gov/macrocryst/

NE-CAT

(Sector 24) The Northeastern Collaborative Access Team scientists are involved in a wide range of research projects. Particular emphases are placed on signal transduction, DNA transcription initiation and regulation, cell cycle regulation, virus structure and function, membrane proteins, protein folding, and enzyme structure and function. Many of the research projects focus on how biological molecules interact to form large macromolecular complexes. The macromolecules studied by NE-CAT members often involve large unit cells, small crystals, weakly diffracting crystals, and crystals with weak anomalous scattering, requiring ultra high resolution data. The NE-CAT is constructing three beam stations two of which have been completed and are now accepting general users.In April of 2007 work commenced on moving beamline 8-BM to 24-BM. NE-CAT consists of six member institutions: Columbia University, Cornell University, Harvard University, Memorial Sloan Kettering Cancer Center, Rockefeller University, and Yale University.

Bio-CAT

(Sector 18) Biophysics Collaborative Access Team is an NIH supported Research center for the study of the structure and dynamics of partially ordered biological systems ( x-ray scattering, fiber diffraction, and x-ray absorption spectroscopy with emphasis on time resolved, spatially resolved, and polarized x-ray experiments, and development of novel techniques). BIO-CAT is member of the Illinois Institute of Technology's (IIT) Center for Synchrotron Radiation Research and Instrumentation (CSSRI

GM/CA-CAT

(Sector 23) The (GM/CA-CAT) has been established by the National Institutes of Health's (NIH)National Institute of General Medical Sciences (NIGMS) and National Cancer Institute (NCI) to build and operate a national user facility for crystallographic structure determnation of biological macromolecules by x-ray diffraction. It is part of the Bioscience Division (BIO) at Argonne National Laboratory (ANL)

SGX-CAT

the Structural GenomiX CAT(sector 31), is designed for high-throughput crystallography in support of a proprietary research program in structural genomics. Funded entirely by Structural GenomiX (SGX),a San Diego-based biotechnology company(http://www.sgxpharma.com/) ,SGX-CAT is the first beamline facility at the Advanced Photon Source to be owned and operated by a single commercial entity.

MCSG

Midwest Center for Structural Genomics Research, is determining novel protein folds; proteins unique to pathogenic organisms; proteins unique to eukaryota; synchorotron-based X-ray crystallography methods; robotic technology development. MCSG is using beamlines at APS in SBC-CAT and DND-CAT.

NESG

Northeast Structural Genomics Consortium, is targeting proteins from various model organisms, and related human proteins. Will use both X-ray and NMR methods. Using beamlines at APS.

SECSG

Southeast Collaboratory for Structural Genomics, is using targets from human genome and two model organisms, the roundworm C. elegans and the microbe P. furiosus. Will use crystallography and NMR. Using SER-CAT at APS.